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KMID : 1039420190530010013
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Journal of Pathology and Translational Medicine
2019 Volume.53 No. 1 p.13 ~ p.22
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Prognostic Role of S100A8 and S100A9 Protein Expressions in Non-small Cell Carcinoma of the Lung
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Koh Hyun-Min
An Hyo-Jung
Ko Gyung-Hyuck
Lee Jeong-Hee
Lee Jong-Sil
Kim Dong-Chul
Yang Jung-Wook
Kim Min-Hye
Kim Sung-Hwan
Jeon Kyung-Nyeo
Lee Gyeong-Won
Jang Se-Min
Song Dae-Hyun
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Abstract
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Background: S100A8 and S100A9 have been gaining recognition for modulating tumor growthand metastasis. This study aimed at evaluating the clinical significance of S100A8 and S100A9 innon-small cell lung cancer (NSCLC).
Methods: We analyzed the relationship between S100A8and S100A9 expressions, clinicopathological characteristics, and prognostic significance in tumorcells and peritumoral inflammatory cells.
Results: The positive staining of S100A8 in tumorcells was significantly increased in male (p < .001), smoker (p = .034), surgical method other thanlobectomy (p = .024), squamous cell carcinoma (SQCC) (p < .001) and higher TNM stage (p = .022)compared with female, non-smoker, lobectomy, adenocarcinoma (ADC), and lower stage. Theproportion of tumor cells stained for S100A8 was related to histologic type (p < .001) and patientsex (p = .027). The proportion of inflammatory cells stained for S100A8 was correlated with patientage (p = .022), whereas the proportion of inflammatory cells stained for S100A9 was correlatedwith patient sex (p < .001) and smoking history (p = .031). Moreover, positive staining in tumorcells, more than 50% of the tumor cells stained and less than 30% of the inflammatory cellsstained for S100A8 and S100A9 suggested a tendency towards increased survivability in SQCCbut towards decreased survivability in ADC.
Conclusions: S100A8 and S100A9 expressions might be potential prognostic markers in patients with NSCLC.
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KEYWORD
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S100A8, S100A9, Carcinoma, non-small cell lung, Prognosis
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